Colts vs 49ers odds
The Indianapolis Colts will travel to San Francisco to face the 49ers this Sunday Night October 24, 2021 at 8:15pm et.
The DraftKings NFL Odds have the 49ers as a -4 point favorite against the spread and -195 on the money line and the over/under is currently at 43 total points.
The NFL betting public loves the 49ers is this one and have 52% of their money behind San Fran as the -4 point road favorite.
Indianapolis Colts Betting Preview
The Colts come into this game 2-4 overall this season after destroying the Houston Texans 31-3 last Sunday. In that game, Quarterback Carson Wentz went 11 of 20 for 223 total yards and 2 touchdowns, but the story was all about their rushing attack. Running back Jonathan Taylor had a very impressive game with 14 carries for 145 total yards and two touchdowns. Taylor should be able to have another great permanence in this one since he’ll be going up against this 49ers defense that is giving up an average of 113 rushing yards per game.
Expect Taylor to get even more carries this game since the passing game Parris Campbell and TY Hilton didn’t practice this week and currently listed as questionable.
On the road this season, the Colts are scoring an average of 22.7 points per game, but on defense they are giving up an average of 24.3 points per game.
Indianapolis is 4-1 against the spread in their last 5 games and the total has gone over in 5 of the Colts last 6 games on the road.
San Francisco 49ers Betting Preview
The San Francisco 49ers come into this game off a bye week at 2-3 overall They last played two Sundays ago where the 49ers got the 17-10 road loss to the Arizona Cardinals.
Jimmy Garoppolo missed that game due to his calf injury, but is set to return to start after being out the last three weeks. Left tackle Trent Williams isn’t expected to play so all eyes will be on how much pressure this Colts team can bring to a banged up Jimmy G. They can’t afford to have him hurt since backup quarterback Trey lance is also out.
Indianapolis ranked 22nd in the league when it comes to converting third downs, so 49ers game plan will be to make sure those struggling numbers continue.
The 49ers at home this season are scoring an average of 24.5 points per game. San Franciso’s defense when playing at home this season is giving up an average of 29 points per game.
The 49ers are 0-6 straight in their last 6 games at home and the total has gone over in 5 of San Francisco’s last 6 games against an opponent in the AFC South.
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