Arizona Cardinals vs San Francisco 49ers NFL Week 1 Picks

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NFL Week 1 Sports Betting Preview between the Arizona Cardinals vs San Francisco 49ers.

This game is set to kickoff Saturday, September 13th at 4:25pm et at the Levi’s Stadium in Santa Clara, California. The 49ers are a -6.5 point favorite with the over/under currently at 48 total points.

The betting public has 69% of their money on the 49ers as the road underdogs.

These two teams last met in November of 2019, where Jimmy G passed for 424 yards and 4 touchdowns in a 36-26 San Francisco home win.

Arizona comes into this game with a lot of hype behind them after making a ton of changes in the offseason. They traded their banged up running back, David Johnson and a couple of second round draft picks for one of the top receivers in the game, DeAndre Hopkins. They also acquired two stud linebackers and a quality defensive lineman while also improving their offensive line. Last season, Arizona lost twice to San Francisco but put up a fight in both games. Arizona is 4-0-1 against the spread in their last 5 games against San Francisco and the total has gone over in 4 of the Cardinals last 6 games against an opponent in the NFC.

San Francisco comes into this game with one of the top offenses in the nation to go along with a top 10 defense. They were the ranked #2 for first half points at home last season and I fully expect them to come out the gate strong to take the early lead. San Francisco is 6-3 against the spread in their last 9 games and the total has gone over in 4 of the 49ers last 5 games against an opponent in the NFC West division.

Our numbers show the best opportunity to make money in this Cardinals vs 49ers game is to take the 49ers First Half -3.5 at the -105 price.

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