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Cubs vs Dodgers MLB Picks and Predictions for April 12

Expert MLB Picks and Predictions for the Chicago Cubs vs Los Angeles Dodgers game on Saturday April 12, 2025.

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While the Cubs have looked sharp early in the season, there’s been one major problem — the Dodgers.

After a 3-0 loss Friday night, Chicago is now 0-3 vs Los Angeles this season, averaging just 1.3 runs per game across those matchups. They dropped two to the Dodgers in Tokyo, and couldn’t solve the puzzle again in the series opener at Dodger Stadium — where L.A. remains a perfect 7-0 at home.

📉 Pitching Mismatch Alert
The Cubs roll out Ben Brown (1-1, 7.71 ERA), who’s been shaky early — five earned runs in four innings his last start vs the Padres. He already saw the Dodgers once this season, giving up 3 runs in under 3 innings of relief work in Japan.

Los Angeles counters with rookie Roki Sasaki, who showed improved command in his latest outing, allowing just one run over four innings against Philly. If Sasaki limits walks, he’ll have a massive advantage over a Cubs lineup that’s looked completely outmatched at the plate vs Dodgers pitching.

💣 Offensive Edge
Tommy Edman has been a catalyst for this Dodgers lineup. He launched a game-breaking 3-run homer Friday and is now tied for the NL lead in home runs (6). With the way he and this offense are seeing the ball — and considering how efficient L.A.’s bullpen has been — this is not a great setup for a bounce-back spot for Chicago.

🔒 Bottom Line
The Cubs are running into a buzzsaw. Their offense can’t get going, their starter is vulnerable, and the Dodgers are dominant at home. L.A. has every edge you want to see — lineup form, pitching, momentum, and ballpark edge.

This isn’t just another early-season series — it’s a real opportunity for bettors who know how to spot one-sided matchups.

Take: Dodgers Team Total Over 4.5 Runs +100

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